School of Medicine - Basic Medical SciencePhysiology II

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生理学Ⅱ2016

We are focusing our research interests on (1) circulatory physiology, (2) cardiac electrophysiology, and (3) autonomic nervous system physiology.
(1) Studies of the circulatory (patho)physiology are being performed under the direction of Professor Shibamoto, using whole animals and excised perfused organs of mice, rats, and others. The studies include (1) pathophysiological mechanisms and treatments of circulatory shocks, especially anaphylactic shock, and (2) mechanisms for the control of regional circulations in the lung, liver, abdominal cavity, and heart of the animals as experimental models of circulatory shock, ischemia/reperfusion, obesity, and so on.
(2) Studies of cardiac electrophysiology are being conducted mainly by Dr. Kurata. He is investigating the functions of cardiac ion channels and mechanisms of normal and abnormal automaticity in the heart by the path-clamp experiment and theoretical methods using mathematical models of cardiac myocytes.
(3) Studies of the autonomic nervous system are being conducted mainly by Dr. Tanida. He is investigating the roles of autonomic nerve systems in controlling the central nervous system functions by physiological and molecular biological methods.
In education, we give lectures and practical training on the functions of respiratory, cardiovascular, and endocrine systems to the junior year medical students.

Contact Information

TEL: 076-286-2211(内線3644) +81-76-286-2211 / FAX: 076-286-8010 +81-76-286-8010 / Email: physiol2@kanazawa-med.ac.jp

Faculty

Professor and Chair

  • SHIBAMOTO Toshishige 芝本写真

Professor

  • KURATA Yasutaka

Associate Professor

  • TANIDA Mamoru

Assistant Professor

  • KUDA Yuhichi

Adjunct Lecturer

  • MAEDA Masanobu

Collaborative Researcher

  • WANG Mofei

Visiting Research Fellow

  • YANG Wei

Research Achievements

Research Activities

  • Song J, Tanida M, Shibamoto T, Zhang T, Wang M, Kuda Y, Kurata Y. The role of lumbar sympathetic nerves in regulation of blood flow to skeletal muscle during anaphylactic hypotension in anesthetized rats. PLoS One 11: e0150882, 2016.
  • Wang M, Shibamoto T, Kuda Y, Tanida M, Zhang T, Song J, Kurata Y. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. Life Sci 147: 77-84, 2016.
  • Tanida M, Gotoh H, Yamamoto N, Wang M, Kuda Y, Kurata Y, Mori M, Shibamoto T. Hypothalamic nesfatin-1 stimulates sympathetic nerve activity via hypothalamic ERK signaling. Diabetes 64: 3725-3736, 2015.
  • Tanida M, Yamamoto N, Morgan DA, Kurata Y, Shibamoto T, Rahmouni K. Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated proteinkinase. J Neurosci 35: 474-484, 2015.
  • Kurata Y, Hisatome I, Tanida M, Shibamoto T. Effect of hyperpolarization-activated current If on robustness of sinoatrial node pacemaking: theoretical study on influence of intracellular Na+ concentration. Am J Physiol Heart Circ Physiol 304: H1337-H1351, 2013.

External Research Funding

  • Shibamoto T. Grant-in-Aid for Scientific Research (C) (2016-2018, delegate) The roles of angipoietin 2 in anaphylactic shock. ¥3,900,000.
  • Kurata Y. Grant-in-Aid for Scientific Research (C) (2014-2016, delegate) Theoretical study on the mechanisms for automaticity of human stem cell-derived cardiomyocytes with application to biopacemaker engineering, ¥3,800,000.
  • Kurata Y. Grant-in-Aid for Scientific Research on Innovative Areas (2013-2014, delegate) Studies on the dynamical mechanisms of spontaneous activities of human cardiac myocytes and their regulations based on bifurcation theory (In High Definition Physiology). ¥5,400,000.
  • Tanida M. Grant-in-Aid for Scientific Research (C) (2016-2018, delegate) Studies on the mechanism for the activation of the sympathetic nervous system of the adipose tissue by nesfatin-1. ¥4,680,000.
  • Tanida M. Grant-in-Aid for Young Scientists (B) (2014-2015, delegate) Regulation of autonomic nerves innervating liver and pancreas by leptin and application to improvement of glucose metabolism. ¥4,030,000.